Prevention: wrestling with new economic realities

Wrestling with Uncertainty in Climate Economic Models‡

This paper uses insights from decision theory under uncertainty to explore research challenges in climate economics. We embrace a broad perspective of uncertainty with three components: risk (probabilities assigned by a given model), ambiguity (level of confidence in alternative models), and misspecification (potential shortfalls in existing models). We survey recent climate science research th...

New Realities of the Enterprise Management System Information Support: Economic and Mathematical Models and Cloud Technologies

The paper focuses on the urgency of the implementation of cloud technologies, which are a necessary condition for the development of enterprise management systems, give rise to a complex of insufficiently studied phenomena and processes and determine the need to find new tools in making and implementing reasonable management decisions. In the process of research, the sequence of construction an...

Organizational Effectiveness: New Realities

SUMO wrestling with Ras

This review discusses our current understanding of the small ubiquitin-like modifier (SUMO) pathway and how it functionally intersects with Ras signaling in cancer. The Ras family of small GTPases are frequently mutated in cancer. The role of the SUMO pathway in cancer and in Ras signaling is currently not well understood. Recent studies have shown that the SUMO pathway can both regulate Ras/MA...

Wrestling with rep exposure

A central methodological problem in programming with multiple levels of abstractions is the loosely defined problem of rep exposure. This paper traces the problem of rep exposure to the precisely defined notion of abstract aliasing. The paper also outlines a statically-enforceable discipline for avoiding abstract aliasing, but the outline is incomplete.